Psychedelics disrupt the functional hierarchy of the human brain

This was my PhD thesis! Here is the link to the full manuscript. Abstract: Psychedelics, such as lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), and psilocybin, are hallucinogenic drugs that act on the 5-HT2A receptor. Their effects can be analysed on three different levels: (1) phenomenology, or subjective experience, as psychedelics strongly alter a person’s state […]

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LSD flattens the hierarchy of directed information flow in fast whole-brain dynamics

Currently in press at Imaging Neuroscience. Here is the full article. Abstract: Psychedelics are serotonergic drugs that profoundly alter consciousness, yet their neural mechanisms are not fully understood. A popular theory, RElaxed Beliefs Under pSychedelics (REBUS), posits that psychedelics flatten the hierarchy of information flow in the brain. Here, we investigate hierarchy based on the […]

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